Use of Artemisia Annua for malaria treatment

Malaria! The name sends shivers down the spine. Only those who’ve faced it know how it feels to have malaria. Governments tried to eradicate it, drugs worked for a time and then became redundant until Artemisia annuaor A. annuaor sweet wormwood, came along.  

Meghalaya’s traditional healers also know about this herb.

The Khasis call it ‘u bat jaiaw and use it to treat ‘ka khiehshoh rih’ otherwise known as malarial fever. The Garos call it ‘khel bijek’ and use it to relieve headaches. 

Artemisia Annua plant found in Meghalaya
Relentless March

It may not be among the top 10 fatal diseases in the world, but malaria is a singularly cruel one. It smites relentlessly, especially children, causing many other complications if not treated on time. 

Millions have died because of it and the death rate continues. According to the WHO, in 2018 alone, it affected 228 million people and killed 405,000! 

Of course, scientists have been working hard since the beginning of the last century and they have brought out miraculous cures. Antimalarial drugs, like quinine and chloroquine, have saved millions of lives in the last one hundred years. 

But, as it turned out, the effects were short-lived. Complete eradication remains as elusive as ever. Why?

The malarial parasites have always managed to outsmart by mutating and developing resistance against these curesDoctors soon found out that, after a few decades, the wonder-drugs stopped being that wondrousAnd scientists kept themselves busy scrambling to find newer medicines.  

That’s how they stumbled upon Artemisia annua.  

What’s Artemisia Annua or Sweet Wormwood? 

It’s an annual herb that belongs to the plant family of Asters (Asteraceae). If you didn’t know it, you might mistake it for a common weed, such as the common ragweed. 

is its native place but now we find it growing all over the world. Sweet wormwood or Artemisia annua thrives best in temperate and cool climates and higher altitudes.  

sweet wormwood grows up to a height of 30 to 100 cm but the specially cultivated ones can reach up to 200 cm. The flowers are yellowish-green and small – 3 to 5 cm in diameter. The seeds are single and tiny, without pappus and so can’t be dispersed by the wind. 

Sweet wormwood’s most valuable parts are t
he leaves. They’re small, about 3 to 5 cm long, each divided into three leaflets by deep cuts. Their odour is intensely aromatic. Scientists say this is because of its main chemical, artemisinin, which is present between 0% and 1.5% in dried leaves.  

Artemisinin is the most important bioactive principle of sweet wormwood and 
the most sought after for its medicinal properties 

A Meghalaya Story 

I remember Grandpa telling us a story of how, long ago, the ancestors of his village, Mawphlang, had to abandon a huge territory in the plains of Assam because of fear of malaria. They were invited to settle in that place and preside over it as chiefs.  
They went. But they soon hurried back. The reason? They had lost quite a few lives in quick succession to a strange sickness that made one ‘burn like fire and shake like leaves!’ 

It was malaria. They call
ed it ‘ka khieshoh rih’.  

And so, even till Grandpa’s time, he said, people from the village wouldn’t even venture out closer home to Ri-Bhoi! So afraid were they of malaria! Once it struck, there was no escape. 

What A Healer Told Me

But Khasi traditional healers knew how to manage malarial fevers. That’s what Kong Ribhahealer from Umtyrniut, near Mawphlang, told me.  
I spoke to Kong to find out if she knew about sweet wormwood. I also sent a picture of it on WhatsappPat came the reply. 

"This is ‘u bat jaiaw', we use it to treat malaria, blood problems, and stomach problems such as constipation. You see we healers make what we believe are the correct remedies only after studying the patient’s case history. We first must find out the real underlying problems. Because they may be multiple and have many other complications. It is seldom that we use only a single herb. We generally combine two, three, or even six or seven herbs, depending upon the patient’s particular condition. Sometimes we prepare poultices and powders. At other times make decoctions to be taken internally. Or, we may use an oil or paraffin base for topical application. Again, there are remedies meant as baths or hot fomentations."  
"What about 'u bat jaiaw'…how do you use it, for example, in malaria?’"  
"In case of fevers or malaria, we make a decoction of the leaves of 'u bat jaiaw' and that of another herb, 'u sharita' (U sharita - Swertia chirayita – is commonly called ‘chiretta’ in English, and 'chirayata' in Hindi). These two are simmered over a low flame for about two hours. We then allow the decoction to stand and cool. After that we decant the liquid into bottles, usually one-litre ones. We advise the patient to take about a quarter of a cup, three or four times a day. The duration of the treatment can continue for two-three months, depending upon the severity of the case. Healers generally prepare decoctions to last for about two to four weeks, initially."
"The plant 'U bat jaiaw' has one very practical use also, if you are prone to sinusitis attacks, pluck a few leaves, bruise them between fingers and inhale. The oils from the leaves will give you relief almost immediately."

What about the Other Northeast Tribes? 

Here’s how some North-east tribes use sweet wormwood: 
  • The Garos call it ‘khel-bijak’ or ‘sak suk’. They make a poultice of fresh leaves along with those of another plant, montori’ (Capparis assamica), and then apply that paste on the forehead to get relief from headaches.  Also, when the nose bleeds, they stuff the poultice inside the nostrils. It stops the bleeding. 
  • The Assamese call it tongloti or domona. They drink the leaf juice to relieve nervous tensions and spasms. They also use the juice from floral shoots for relief from asthmatic symptoms. 
  • For the Nagasleaf juice is an effective remedy against skin allergies and itches. (It’s now found that Artemisia is very effective against leishmaniasis, an infectious skin disease). 
  • The Mompas of Arunachal Pradesh apply poultice from the leaves to heal sores. 

Artemisia Annua plants growing in a Meghalaya home

How Does Artemisinin Work? 

Here’s what these researchersfound outA malarial parasite’s life cycle follows certain biochemical pathways in the blood that consist of proteins (haemoglobin). Artemisinin works by binding itself ‘indiscriminately’ to these proteins. That’s like cutting down on the germ’s survival supply threshold.  
The parasites need haemoglobin for survival and growth. Artemisinin too needs haem for activation. Haem is the iron-containing component of haemoglobin.  
During the ‘fever’ stage of malaria, the parasite eats the haemoglobin in the blood and fills itself with haem. Artemisinin binds itself to the haem and so stifles the life out of the germ. 

Post-doctoral researcher Leila S. Ross of Columbia University says, “Artemisinin kills by jamming up a large variety of cellular processes rather than a single pathway.” 

Since the important discovery of artemisinins, Artemisinin-based combination therapies (ACT) are now recommended by WHO. These types of therapies are found to swiftly reduce the number of P.falciparum malarial parasites in the blood. 

Rich Plant Chemicals

Scientists have found an astonishing 839 plant chemical constituents in the Artemisia species. These include both volatile and non-volatile compounds. 
Some major compounds are the phenylpropanoids, phenolics, and terpenes. The health 
benefits they can give to humans is astounding. They may be useful in: 
  • Reducing pain 
  • Fighting and killing germs 
  • Reducing inflammation
  • Reducing oxidative stress 
  • Reducing depression and anxiety 
  • Heal sores and skin diseases 

Artemisia species are useful even as an insecticide, larvicide and sources of nutrition. 

Artemisia Vulgaris also found commonly in MeghalayaArtemisia vulgaris or Mugwort – another species of Artemisia 

Getting the Best out of Wormwood

Sweet wormwood is a great herb. It has amazing anti-microbial properties that are super effective against numerous gram-positive and gram-negative bacteria and fungi. 

The q
uestion now is…how do you get hold of it for your everyday use?  

Get hold of Artemisia annua essential oil or hydrosolsThese products come packed in convenient vials and cans; very handy and easy to use. 

Use a drop or two of essential oil in your baths. Use it in aromatherapy to relieve yourself of tension headaches or relax and calm your mind. Or sniff it when you have a sneezing spree! 

Oils made from Artemisia Annua

Hydrosols are the ‘water portion’ of the distillate that comes along with the essential oilThey're 100% pure, coming as they do with the steam, and they are amazingly handy productsUse hydrosols for skincare, aromatherapy, linen sprays, body sprays, room fresheners and more. 

To End the Story… 

We, at  Zizira, sure hope you enjoyed this blog about the amazing sweet wormwood, 'Artemisia annua', or 'u bat jaiaw'. 
We’re sure you too have something to say or stories to share. Why not comment here? Or, maybe you’d like to know more about us and our product range? 

click here! 

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